Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2062 | 2062-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, L76V, I84V, L90M | G73S, L89V | L10I, V11L, I13V, I15V, Q18H, K20I, E34Q, E35D, M36I, N37ND, D60E, I62V, L63P, A71L, I72L, I93L |
| >2062-30623| codons 4-99 TLWQRPILTVKVGGHLIEALLDTGADDTVLQDIDLPGRWKPKIVGGIGGFLKVRQYEQVP IEICGHKLLSTVVVGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | Y181C, G190A | K101H, V108I, F227L | T39E, E44D, V60I, K103R, V118I, K122E, D123N, I135T, I142V, D177EG, V189I, G196E, E203K, Q207E, H208Y, H221Y, K223E |
| >2062-30623| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLHKRKSVTILDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIVICQYVDDLYIASDLEIEQHRTKIKELREYLWRWGFYTP DNKYQEEPPLLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |