<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1738 1738-30617 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215F V75M, K219Q Y181V V108I T39E, E44D, V60I, A98S, V118I, K122E, I142V, S162D, E169K, K173E, V179I, I195IL, G196E, T200A, E203V, Q207E, R211K, D218E, F227FY, L228K, V245E V111VL, I132IK
>1738-30617| codons 38-247
CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP
SGLKKKKSVTILDLGDAYFSIPLDEDFRKYTAFTKPSINNETPGVRYQYNVLPQGWKGSP
AIFQDSMTKILKPFREQNPDIIIVQYVDDLYVGSDLELEQHRAKIVELREHLWKWGFFTP
EQKHQKEPPYKWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I50V, I54S, V82A L33F, K43T Q7E, L10IV, I13IV, G16A, E34Q, R41K, L63T, A71V, V77I, I93L  
>1738-30617| codons 4-99
TLWERPVVTVKIAGQLKEALLDTGADDTVFQEMNLPGKWTPKMIVGVGGFSKVRQYDQIT
IEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006