Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1738 | 1738-30617 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54S, V82A | L33F, K43T | Q7E, L10IV, I13IV, G16A, E34Q, R41K, L63T, A71V, V77I, I93L |
| >1738-30617| codons 4-99 TLWERPVVTVKIAGQLKEALLDTGADDTVFQEMNLPGKWTPKMIVGVGGFSKVRQYDQIT IEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215F | K219Q | Y181V | V108I | T39E, E44D, V60I, A98S, V111VL, V118I, K122E, I142V, S162D, E169K, K173E, V179I, I195IL, G196E, T200A, E203V, Q207E, R211K, D218E, F227FY, L228K, V245E | I132IK |
| >1738-30617| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTILDLGDAYFSIPLDEDFRKYTAFTKPSINNETPGVRYQYNVLPQGWKGSP AIFQDSMTKILKPFREQNPDIIIVQYVDDLYVGSDLELEQHRAKIVELREHLWKWGFFTP EQKHQKEPPYKWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |