Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1736 | 1736-30418 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48AS, I54V, V82A, L90M | K43T, G73S | L10I, V11L, T12E, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I72R, I85IV |
| >1736-30418| codons 4-99 TLWQRPILEIKVGGQLIEALLDTGADDTVLEDINLPGRWTPKMISGIGGFVKVRQYDQVP IEICGHKVRSTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, M184V, L210W | A62V, T215E, K219Q | Y188FL | K64H, T69N, V90VI, V111I, V118I, I135T, S162A, T165TI, R172K, D192H, R211RK, F214L, D218E, L228H, Q242QH, V245VE |
| >1736-30418| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIHKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDIGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQASMIKILEPFKKQNPDIVIYQYVDDLLVGSHLEIGQHRTKIEELRQHLWKWGLETP EQKHQKEPPFHWMGYELHPDKWTVHPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |