Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1270 | 1270-30403 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L74LI, V75VAIT, L210LW, T215TNSY | K219KN | Y181C | V108I | S68SG, D121HY, K122E, K173N, Q174K, D177E, I178IL, R211K, H221HY, L228LH, P243PT, V245VE |
| >1270-30403| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDGTKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSVPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRNKNPELVICQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DNKYQKEPPFHWMGYELHPDKWTVQTIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IV, V82VA | L24LI, Q58QE | L10LI, R41RK, L63LP, I72V |
| >1270-30403| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVREYDQIP IEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |