Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1268 | 1268-30314 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, V82A, L90M | L33F, M46V | L10I, K14R, E34Q, R41K, K55R, L63P, A71V, I72V |
| >1268-30314| codons 4-99 TLWQRPIVTIRIGGQLKEALLDTGADDTIFQEMNLPGKWKPKVVGGIGGFMRVRQYDQIP IEICGHKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103N | K43N, V60I, V118I, K122E, I135V, T139K, S162C, G196E, E203D, R211K | D185DG |
| >1268-30314| codons 38-247 CTELENEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNEKPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYMGDLYVGSDLEIEQHRTKIDELRQHLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |