<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1265 1265-30303 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, M184V, L210W, T215Y V75M K103N A98G, V108I K43E, E44A, S68G, V118I, K122E, D177E, V189I, T200A, E203D, R211K, K223Q, L228H  
>1265-30303| codons 38-247
CTELEEAGKISKIGPENPYNTPVFAIKKKDGTKWRKIMDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYIGSDLEIGQHRAKIDELRQHLWKWGFYTP
DKKHQQEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84IV L24I, L33LF, Q58QE W6WR, L10I, I13IV, K20R, E35D, M36I, N37D, R41RK, I62V, L63P, A71V, I93L  
>1265-30303| codons 4-99
TLRQRPIVTVKIGGQLREALIDTGADDTVFEDIDLPGKWKPKIIGGIGGFVKVREYDQVP
IEICGHKVIGTVLVGPTPANVIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006