Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1265 | 1265-30303 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84IV | L24I, L33LF, Q58QE | W6WR, L10I, I13IV, K20R, E35D, M36I, N37D, R41RK, I62V, L63P, A71V, I93L |
| >1265-30303| codons 4-99 TLRQRPIVTVKIGGQLREALIDTGADDTVFEDIDLPGKWKPKIIGGIGGFVKVREYDQVP IEICGHKVIGTVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, V75M, M184V, L210W, T215Y | K103N | A98G, V108I | K43E, E44A, S68G, V118I, K122E, D177E, V189I, T200A, E203D, R211K, K223Q, L228H |
| >1265-30303| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKDGTKWRKIMDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYIGSDLEIGQHRAKIDELRQHLWKWGFYTP DKKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |