Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1260 | 1260-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151KM | T215TI, K219Q | K101E, G190A | T69S, V106I, D121HY, K122E, D177E, V179VA, F214L, V245M |
| >1260-30318| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSSRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSITVLDVGDAYFSVPLYEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPEIAIYQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGLITP DQKHQKEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L23I, Q58E | L10IV, I15V, G16GA, L63A, A71V, I93L |
| >1260-30318| codons 4-99 TLWQRPVVTIKVAGQLKEAILDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVREYDQIA IEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |