<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2378 2378-30811 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115YF, Q151M K70T, V75I, F77L, F116Y Y181C, G190A V108VI T39A, S68G, T69I, R83K, K101Q, V118VI, K122E, I178L, T200A, E203EQ, Q207DG, L210LF, F214L, L228LH  
>2378-30811| codons 38-247
CAEMEKEGKISKIGPENPYNTPVFAIKRKDGITWRKLIDLRELNKKTQDFWEVQLGIPHP
AGLQKKKSVTILDVGDAFYSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP
AIFQSSMTKILEPFRKQNPDLVICQYMDDLYVASDLEIGQHRAKIQELRGHLFRWGLTTP
DKKHQKEPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A L33F, G73C L10I, I13V, K20R, E35D, M36V, N37D, I62V, L63P, I93L  
>2378-30811| codons 4-99
TLWQRPIVTVKIGGQLREALLDTGADDTVFEDVDLPGRWKPKIIGGVGGFVKVRQYDQVP
IEICGHKAICTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006