Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2378 | 2378-30811 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A | L33F, G73C | L10I, I13V, K20R, E35D, M36V, N37D, I62V, L63P, I93L |
| >2378-30811| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDVDLPGRWKPKIIGGVGGFVKVRQYDQVP IEICGHKAICTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115YF, Q151M | K70T, V75I, F77L, F116Y | Y181C, G190A | V108VI | T39A, S68G, T69I, R83K, K101Q, V118VI, K122E, I178L, T200A, E203EQ, Q207DG, L210LF, F214L, L228LH |
| >2378-30811| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKRKDGITWRKLIDLRELNKKTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAFYSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDLVICQYMDDLYVASDLEIGQHRAKIQELRGHLFRWGLTTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |