Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2045 | 2045-40505 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 44 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V | L10I, T12S, I13V, K20M, M36I, L63P, I64V |
| >2045-40505| codons 1-99 PQITLWQRPIVSVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGHKAIGTVLVGPTPFNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | Y188L | V35L, T39A, K43E, V60I, V106I, V118I, K122E, I135M, S162N, T200A, R211K, L228H, V245K, A272P, T286A, E297K, K311R, D324E, R356K, M357R, G359S, D364E, A371V, K390R | S191SF |
| >2045-40505| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYVDDLLVGFDLEIGQHRAKIEELRQHLWKWGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKRRSA HTNEVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |