Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2045 | 2045-30702 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V | L10I, T12S, I13V, K20M, M36I, L63P, I64V |
| >2045-30702| codons 4-99 TLWQRPIVSVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQIP VEICGHKAIGTVLVGPTPFNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | Y188L | T39A, K43E, V60I, K102KM, V106VI, V118I, K122E, S162N, T200A, R211K, L228LH, K238KR, V245EK |
| >2045-30702| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKMKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRAKIEELRQHLWKWGFYTP DRKHQKEPPFHWMGYELHPDRWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |