Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1256 | 1256-30520 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V75VALS | Y181IV, G190A | V179VE | T39EK, K43E, E44ED, K101Q, K103KR, V118I, K122E, S162SG, S163SG, T165TI, K166KR, I202IV, Q207E, K223Q, V245EQ | E203EAKT |
| >1256-30520| codons 38-247 CKELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKVSDFRELNKRTQDFWEVQLGIPHP AGLQKRKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQGGMIRILEPFRKQNPDIEIVQYVDDLYVASDLEIGQHRTKVTELREHLWRWGFYTP DKKHQQEPPFLWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10F, L24I, L33F, K43T, G73C | I15V, K20MT, E35N, M36I, N37D, K55R, R57K, D60E, Q61R, I62V, L63P, A71V, I72E |
| >1256-30520| codons 4-99 TLWQRPFVTIKVGGQLTEALIDTGADDTVFENIDLPGRWTPKLIGGIGGFVRVKQYERVP IEICGHKVECTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |