<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1256 1256-30520 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L10F, L24I, L33F, K43T, G73C I15V, K20MT, E35N, M36I, N37D, K55R, R57K, D60E, Q61R, I62V, L63P, A71V, I72E  
>1256-30520| codons 4-99
TLWQRPFVTIKVGGQLTEALIDTGADDTVFENIDLPGRWTPKLIGGIGGFVRVKQYERVP
IEICGHKVECTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y V75VALS Y181IV, G190A V179VE T39EK, K43E, E44ED, K101Q, K103KR, V118I, K122E, S162SG, S163SG, T165TI, K166KR, I202IV, Q207E, K223Q, V245EQ E203EAKT
>1256-30520| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKVSDFRELNKRTQDFWEVQLGIPHP
AGLQKRKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQGGMIRILEPFRKQNPDIEIVQYVDDLYVASDLEIGQHRTKVTELREHLWRWGFYTP
DKKHQQEPPFLWMGYELHPDKWTVQPIQLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006