Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1253 | 1253-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46I, I47V, I54L, I84V, L90M | L10F, L33F, F53L, Q58E | I13IV, G16E, L19LI, K20R, E34EQ, E35D, M36I, N37S, I62V, L63H, A71V, I72V |
| >1253-30318| codons 4-99 TLWQRPFVTVKIEGQIREALLDTGADDTIFQDISLPGRWKPKIVGGIGGLLKVREYDQVH IEICGHKVVGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215FY | Y188L | K43E, V118VI, D123E, I135L, D177E, V179I, T200A, H208Y, R211K, L228H |
| >1253-30318| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIIYQYMDDLLVGSDLEIGQHRAKIEELRQYLLKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |