Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1596 | 1596-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, V82A, L90M | L33F, Q58E, G73S | L10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72L, I85V |
| >1596-30522| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVFEDIELPGRWKPKMIGGIGGFLRVKEYEQVP IEICGHKVLSTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103KN, Y181C | V108VI, F227L | T39K, K43E, S68SG, V118I, K122E, I135V, V179VI, G196E, T200A, I202IV, E203K, H208Y, R211K, H221Y, K223E, L228H |
| >1596-30522| codons 38-247 CKELEEEGKISKIGPENPYNTPVFAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVGSDLEIEQHRAKVKELRQYLWKWGFYTP DNKYQEEPPLHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |