<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1596 1596-30522 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, V82A, L90M L33F, Q58E, G73S L10I, I15V, K20R, E35D, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72L, I85V  
>1596-30522| codons 4-99
TLWQRPIVTIKVGGQLREALLDTGADDTVFEDIELPGRWKPKMIGGIGGFLRVKEYEQVP
IEICGHKVLSTVLVGPTPANIVGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K103KN, Y181C V108VI, F227L T39K, K43E, S68SG, V118I, K122E, I135V, V179VI, G196E, T200A, I202IV, E203K, H208Y, R211K, H221Y, K223E, L228H  
>1596-30522| codons 38-247
CKELEEEGKISKIGPENPYNTPVFAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVGSDLEIEQHRAKVKELRQYLWKWGFYTP
DNKYQEEPPLHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006