Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1818 | 1818-30728 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82VA, N88NS, L90M | L33F, Q58QE, G73S | L10V, I13V, K14R, K20R, E35D, M36I, N37DE, K55R, R57K, I62V, L63P, A71AV, Q92K |
| >1818-30728| codons 4-99 TLWQRPVVTVRIGGQLREALLDTGADDTVFEDIELPGRWKPKLIGGIGGFLRVKEYDQVP IEICGHKVISTVLVGPTPANIIGRSLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | K103N | T39A, K43EQ, E44D, K102R, V118I, K122E, E138A, R211K |
| >1818-30728| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKRNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |