Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1661 | 1661-30404 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73T | L10I, T12DE, I15V, K20I, M36I, K45R, L63P, I64V, C67F, A71V, V75I, I93L |
| >1661-30404| codons 4-99 TLWQRPIVEIKVGGQLIEALLDTGADDTVLEEINLPGRWKPRMIGGIGGFVKVRQYDQIP VEIFGHKVITTILVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70KR, L210W, T215Y | D67H, K219Q | K103N | T39A, K43E, V60I, S68N, T69N, V118I, K122E, I135T, T139M, S162Y, I202V, R211K, L228H | T84TA |
| >1661-30404| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKHNNRWRKLVDFRELNKRAQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNEMPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |