Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1252 | 1252-30324 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | L24I, L33F, Q58E | L10Y, T12P, I13V, G16A, L19P, K20T, M36I, N37D, D60N, L63P, A71V, T91S |
| >1252-30324| codons 4-99 TLWQRPYVPVKIAGQPTEALIDTGADDTVFEEIDLPGRWKPKIIGGIGGFVKVREYNQIP IEICGHKVIGTVLVGPTPTNVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74I, M184V | T215D | K103N | V108I | K122E, D123E, I135M, Q174K, D177E, T200I, I202V, R211RK |
| >1252-30324| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPEIVIYQYVDDLYVGSDLEIGQHRIKVEELRQHLLKWGFDTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |