Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1248 | 1248-30303 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | Y188L | K102W, V118I, K122E, I135T, Q174K, N175Y, G196E, R211K, F214L, D218E, L228H |
| >1248-30303| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKWKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKYPDIVIYQYVDDLLVGSDLEIEQHRTKIEELRQHLLKWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L33F, G73T | L10V, I13V, I15V, K20R, E35D, M36I, N37E, K43Q, K55R, R57K, I62V, L63P, A71V |
| >1248-30303| codons 4-99 TLWQRPVVTVKVGGQLREALLDTGADDTIFEDIELPGRWQPKIVGGIGGFVRVKQYDQVP IEICGHKVITTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |