Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1593 | 1593-30717 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | L19Q, N37NS, K55R, D60E, L63P, I64V, I66V, V77I, P79A |
| >1593-30717| codons 4-99 TLWQRPFVTIKIGGQQKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFVRVRQYEQIP VEVCGHKAITTVLIGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | G190GA | T39TA, T69E, V118I, K122E, I135T, H208Y, R211K, F214L, V245M |
| >1593-30717| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVASDLEIGQHRTKIEELRQYLLKWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |