Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1592 | 1592-30701 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | V11I | L10I, T12P, I13V, I15V, G16E, K20I, Q61K, I62V, L63Q, I64V, A71V, V77I |
| >1592-30701| codons 4-99 TLWQRPIIPVKVEGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYDKVQ VEICGHKVIGTVVIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DY, L210W, T215Y | K103KT | T39TA, K43Q, V60I, K102KR, D123E, S134SG, I135T, D177E, I178L, G196E, T200A, H208Y, R211K, V245E |
| >1592-30701| codons 38-247 CAELEQEGKISKIGPENPYNTPIFAIKKKNSYKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRTKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPGTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYMDDLYVGSDLEIEQHRAKIEELRQYLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |