Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1591 | 1591-30618 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54T, V82A, L90M | K43KT, G73GS | L10I, I15V, G16A, K20L, N37D, L63P, A71L, T74S, V77I, I85V, I93L |
| >1591-30618| codons 4-99 TLWQRPIVTIKVAGQLLEALLDTGADDTVLEEMDLPGRWTPKIIGGIGGFTKVRQYDQIP IEICGHKLISSVLIGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210W, T215F | K219E | K103S, G190GA | V60I, K122E, I135IMV, P170PL, R172RK, D177E, R211K |
| >1591-30618| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILELFKKQNPEIVIYQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFFTP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |