<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1590 1590-30605 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y D67G, K219R   V108I, F227L K43A, E44D, V118I, I135T, Q197P, T200E, E203K, H208Y, R211K, K223E, L228H, V245K  
>1590-30605| codons 38-247
CTELEADGKISKIGPENPYNTPVFAIKKKGSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGPHREKIKELRQYLWKWGFYTP
DRKHQEEPPLHWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L33LF, Q58E, G73GS L10I, E34EQ, R41RK, D60E, L63P, A71V, I72K, V77I, I93L  
>1590-30605| codons 4-99
TLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMNLPGKWKPKLIGGIGGFVKVREYEQIP
IEICGHKVKSTVLIGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006