Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1577 | 1577-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, F53L, T74P, L89V | I13V, K20R, E35D, M36I, G51A, I62V, K70E, A71V, G73V |
| >1577-30507| codons 4-99 TLWQRPFVTVKIGGQLREALLDTGADDTVFEDINLPGRWKPKIIGGIAGLVKVRQYDQVL IEICGHEVIVPVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | Y188L | T39A, E40F, K43E, K49R, K82R, V106L, K122E, T165I, V179VI, T200E, E203K, Q207E, H208Y, K223E, L228H, D237E, V245E |
| >1577-30507| codons 38-247 CAFLEEEGKISRIGPENPYNTPVFAIKKKNSDKWRKLMDFRELNRRTQDFWEVQLGIPHP AGLKKKKSLTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIIIYQYMDDLLVGSDLEIGQHREKIKELREYLWRWGFYTP DKKHQEEPPFHWMGYELHPEKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |