Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1894 | 1894-40825 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 63 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219R | K101KE | V108I | E6EK, K20R, V35M, T39A, K43E, K103KR, V118I, K122E, I202M, H208Y, R211K, H221Y, A272P, T286A, E312EG, I326V, P345L, R358K, G359S, T369V, A371V, I375V, A376S, T386I, K390R |
| >1894-40825| codons 1-400 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKRKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKMEELRQYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKGPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQELFKNLKTGKYARMKSA HTNDVKQLVEVVQKVSTESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82L, I84A | L10V, I15V, G16A, K20R, M36I, N37D, Q61N, I62V, L63P, C67CY, H69HR, A71V, I93L |
| >1894-40825| codons 1-99 PQITLWQRPVVTIKVAGQLREALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVRQYD NVPIEIYGRKVIGTVVVGPTPLNAIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |