<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1894 1894-40825 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 63

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219R K101KE V108I E6EK, K20R, V35M, T39A, K43E, K103KR, V118I, K122E, I202M, H208Y, R211K, H221Y, A272P, T286A, E312EG, I326V, P345L, R358K, G359S, T369V, A371V, I375V, A376S, T386I, K390R  
>1894-40825| codons 1-400
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKRKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKMEELRQYLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKGPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQELFKNLKTGKYARMKSA
HTNDVKQLVEVVQKVSTESIVIWGKIPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, V82L, I84A   L10V, I15V, G16A, K20R, M36I, N37D, Q61N, I62V, L63P, C67CY, H69HR, A71V, I93L  
>1894-40825| codons 1-99
PQITLWQRPVVTIKVAGQLREALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVRQYD
NVPIEIYGRKVIGTVVVGPTPLNAIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006