Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1894 | 1894-30613 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, I84A | L10I, G16A, K20R, M36I, N37D, Q61N, I62V, L63P, C67Y, A71V, I93L |
| >1894-30613| codons 4-99 TLWQRPIVTIKIAGQLREALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVRQYDNVP IEIYGHKVIGTVVVGPTPVNAIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219R | K101E, Y181YC, G190A | V108I | T39A, K43E, E44A, V90VI, K103R, V118I, K122E, S162SN, R172RK, H208HY, R211K, H221Y |
| >1894-30613| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLEKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFKKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |