Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1893 | 1893-30611 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, V82VCFG, I84V, L90M | L10F, Q58E, G73GAST | L19I, L63P, H69R, K70R, I93M, C95F |
| >1893-30611| codons 4-99 TLWQRPFVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYDQIP IEICGRRAITTVLVGPTPGNVIGRNLMTQMGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, L210LW, T215Y | K219E | K103N, Y181C, G190A | T39A, E44D, V118VI, K122KE, K173T, H208HY, R211RK, D218E, L228H |
| >1893-30611| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRTQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |