Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1789 | 1789-30512 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54M, V82A, I84V | L10I, T12E, E35D, M36MI, I62V, L63P, A71V, T74S, I93L |
| >1789-30512| codons 4-99 TLWQRPIVEIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIVGIGGFMKVRQYDQVP IEICGHKVIGSVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | T39A, V118I, D123E, I135T, K166R, E169D, I202IV, Q207E, F214L, L228LH |
| >1789-30512| codons 38-247 CAEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILDPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELREHLLRWGLFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |