Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1787 | 1787-30507 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54M, V82S, L90M | L33F | L10I, I13V, K20T, E34EQ, E35D, M36V, N37DE, I62V, L63P, I64M, H69Q, A71I, I72V, V77I, I93L |
| >1787-30507| codons 4-99 TLWQRPIVTVKIGGQLTEALLDTGADDTVFQDVELPGRWKPKMIVGIGGFMKVRQYDQVP MEICGQKIVGTVLIGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219Q | A98G | S68G, T69E, V90VI, V118I, K122E, I135T, E204Q, Q207E, R211K, F214L |
| >1787-30507| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKGGERWRKLVDFRELNKRTQDFWEIQLGIPHP GGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEQLREHLLKWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |