Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1726 | 1726-30502 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70E, Y115F, Q151M | A62V, V75I, F77L, F116Y | V106A, G190GA | T39TA, T58N, V118I, K122E, Q174K, N175Y, I178M, L187F, G196K, Q197E, T200E, F214L, L228R, I244V, V245E | T165TS |
| >1726-30502| codons 38-247 CAEMEKEGKISKIGPENPYNNPVFVIKKKNSTEWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSATVLDVGDAFYSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMSKILEPFRKKYPDMVIYQYMDDFYVASDLEIKEHREKIEELRQHLLRWGLTTP DKKHQKEPPFRWMGYELHPDKWTVQPVELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A, L90M | L33F, Q58E | L10I, I13V, G16E, I62V, L63T, A71V, V77I, I93L |
| >1726-30502| codons 4-99 TLWQRPIVTVKIEGQLKEALLDTGADDTVFEEMNLPGRWKPKLIVGIGGFSKVREYDQVT IEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |