Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1725 | 1725-30501 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | Y181C, G190A | A98G, V179E | T39E, K103R, V118I, K122E, I135T, I142IT, K173R, G196E, H208Y, R211K, F214L, L228H | N137NH |
| >1725-30501| codons 38-247 CEELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKRKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNHETPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRRQNPDIEICQYVDDLYVASDLEIEQHRTKIEELRQYLLKWGLFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10F, G73T | I13M, K20I, A22V, M36MI, I62V, L63P, I64V, I66IV, V77I, N83NS, I85IV, I93IL |
| >1725-30501| codons 4-99 TLWQRPFVTMKIGGQLIEVLLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQVP VEVCGHKAITTVLIGPTPVSVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |