Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1724 | 1724-30421 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L10F, V11I, L33F, Q58E, G73C | I15IV, K20IV, E34Q, R41K, Q61H, L63R, K70T, A71V, V77I, I85IV |
| >1724-30421| codons 4-99 TLWQRPFITIKVGGQLVEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGFMKVREYDHIR IEICGHTVICTVLIGPTPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215F | K219N | K103N | K49E, D123E, I142K, K166R, Q174N, D177E, I178IV, Q197E, I202V, E203K, Q207A, H208Y, R211K, K223E |
| >1724-30421| codons 38-247 CTELEKEGKISEIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGKRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKNNPEVVIYQYVDDLYVGSDLEIGEHRTKVKELRAYLLKWGFFTP DNKHQEEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |