Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1721 | 1721-30410 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MI, I54L, I84V, L90M | L10F, L33F, G73T | E34Q, K55KR, D60DE, L63P, I64V, I66F |
| >1721-30410| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKIIGGIGGFLRVRQYEQIP VEFCGHKAITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210LW, T215Y | Y188L | A98G | K43E, E44D, K102M, V106I, V118I, K122E, I178IM, V189VI, T200E, E203K, H208Y, R211K, K223Q, L228H, V245T |
| >1721-30410| codons 38-246 CTELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKMKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYVDDLLIGSDLEIGQHREKIKELRQYLWKWGFYTP DKKHQQEPPFHWMGYELHPDKWTVQPITL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |