Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1652 | 1652-30328 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215CY | K219N | Y188L | T39S, E40F, K43E, V118I, K122E, I135T, I142V, S162Y, V179I, G196E, H208Y, R211K, K223Q, L228R, V245T |
| >1652-30328| codons 38-247 CSFLEEEGKISKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIEQHRTKIEELRQYLWKWGFYTP DNKHQQEPPFRWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, T74P | I13M, K20I, E34Q, M36MI, R57RK, I62IV, L63P, I64V, I66IV, G73V, I93L |
| >1652-30328| codons 4-99 TLWQRPFVTMKIGGQLIEALLDTGADDTVLQEINLPGRWKPKIVGGIGGFMKVKQYDQVP VEVCGHKAIVPVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |