Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1650 | 1650-30324 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82A | L24I, F53L | L10I, K20KR, M36I, N37D, L63P, A71T |
| >1650-30324| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVLEEIDLPGRWKPKMIMGIGGLVKVRQYDQIP IEICGHKTIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184V, L210W, T215Y | T69G, K219D | K103N, G190A | K43E, E44D, D67X, S68N, V118I, K173E, T200A, R211K, D218E, L228H, Q242H, V245E | L246MT |
| >1650-30324| codons 38-247 CTELEEDGKISKIGPENPYNTPVFAIKKKXNGRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFREQNPDIVIYQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTP EDKHQKEPPFHWMGYELHPDKWTVHPIETP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |