Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1649 | 1649-30319 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, V82T, L90M | V11I, G73S, L89V | L10I, L63P, A71V, V77I, I85V |
| >1649-30319| codons 4-99 TLWQRPIITIKIGGQLKEALLDTGADDTILEEMNLPGRWKPKMVGGIGGFMKVRQYDQIP IEICGHKVISTVLIGPTPTNIVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | Y181C, G190A | E40F, K43Q, K122E, D123T, I142V, K166R, V179I, T200A, H208Y, R211K |
| >1649-30319| codons 38-247 CTFLEQEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDETFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKIEELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |