Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1245 | 1245-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | F77L, K219N | K103KN | E44ED, T69TS, A98S, V118I, K122E, T200R, Q207E, R211K, L228H |
| >1245-30318| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKDSSKWRKLMDLRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRRKIEELREHLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, I84V, L90M | L10F, V11VI, L89V | I13V, G16A, K20M, L33V, K55R, I62V, L63P, A71V |
| >1245-30318| codons 4-99 TLWQRPFITVKIAGQLMEALLDTGADDTVVEEMNLPGRWKPKIVGGIGGFMRVRQYDQVP IEICGHKVIGTVVVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |