Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1963 | CA7524 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | DDI | 35 |
| 3 | D4T | 31 |
| 4 | 3TC+AZT+IDV | 113 |
| 5 | D4T+DDI+EFV+NFV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L89V | L10I, I13V, L19I, N37D, G51A, D60E, L63P, A71V, I93IL |
| >CA7524| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTVLEEMDLPGRWKPKIIGGIAGFIKVRQYE QIPIEICGHKVIGTVLVGPTPANIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215V, K219Q | K103N | V35L, T69N, D123DE, K166T, V179I, G196E, V245EK, K277R, L279X, T290TA, I293V, P294T, E297K | K263KQ, N265NT, R284RT |
| >CA7523| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTTILEPFRKQNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFVTPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGQLTWASQIYAGIKVRQXCKLLTGTKALAEVVTLTKEAE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |