Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1241 | 1241-30227 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, I84V, L90M | L33F, F53L | L10I, I13V, I15V, K20R, M36L, N37D, I62V, L63P, I66F, A71V |
| >1241-30227| codons 4-99 TLWQRPIVTVKVGGQLREALLDTGADDTIFEELDLPGRWKPKIVGGIGGLLKVRQYDQVP IEFCGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, L210W, T215Y | K219Q | Y181C, G190A | V108I, V179D | K101Q, K122E, D123E, Q197K, D218E, L228H |
| >1241-30227| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTILDVGDAYFSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIDICQYVDDLYVASDLEIGKHRTKIEELRQHLWRWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |