Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2149 | 2149-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, V11I | I13V, K20I, M36I, N37S, R41K, I62V, L63P, A71I, I72L, L89I | T91M |
| >2149-30813| codons 4-99 TLWQRPFITVKIGGQLIEALLDTGADDTVLEEISLPGKWKPKLIGGIGGFVKVRQYDQVP IEICGHKILGTVLVGPTPANIIGRNIMMQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219N | K101E, Y181C, G190A, M230L | E44D, K64Y, S68ST, A98S, V118I, K122E, E138A, Q174HN, H208Y, R211K, W212M, D218E, L228LH |
| >2149-30813| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIYKKGTTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKNNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQYLWKMGFYTP ENKHQKEPPFHWLGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |