<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2149 2149-30813 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L10F, V11I I13V, K20I, M36I, N37S, R41K, I62V, L63P, A71I, I72L, L89I T91M
>2149-30813| codons 4-99
TLWQRPFITVKIGGQLIEALLDTGADDTVLEEISLPGKWKPKLIGGIGGFVKVRQYDQVP
IEICGHKILGTVLVGPTPANIIGRNIMMQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67G, K219N K101E, Y181C, G190A, M230L   E44D, K64Y, S68ST, A98S, V118I, K122E, E138A, Q174HN, H208Y, R211K, W212M, D218E, L228LH  
>2149-30813| codons 38-247
CTELEKDGKISKIGPENPYNTPVFAIYKKGTTKWRKVVDFRELNKRTQDFWEVQLGIPHP
SGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKNNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQYLWKMGFYTP
ENKHQKEPPFHWLGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006