Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2012 | 2012-30612 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | L100LI, Y181I, G190A | K43E, K49R, V60I, K101Q, V118I, K122E, S162D, V179I, I202V, H208Y, R211K, D218E, L228H, V245E |
| >2012-30612| codons 38-247 CTELEEEGKISRIGPENPYNTPIFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGIQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPDIIIIQYMDDLYVASDLEIGQHRTKVEELRQYLLKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, I84V, L90M | V11I, G73S, L89V | L10I, I15V, Q18H, K20I, E35D, M36I, N37D, I62V, L63P, A71V, I72M, P79A, I85V |
| >2012-30612| codons 4-99 TLWQRPIITIKVGGHLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVMSTVLVGATPFNVVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |