Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1768 | 1768-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, V75M, Q151M | F77L, T215D | K103N | V108I | S68G, A98S, K122E, I135V, E138Q, A158S, S162A, R172K, G196E, H221Y | P52T |
| >1768-30522| codons 38-247 CTEMEKEGKISKIGTENPYNTPVFAIKRKDGTRWRKLMDLRELNKRTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSVNNQTPGIRYQYNVLPMGWKGSP SIFQASMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFDTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, V82C, L90M | L10F, L33F, K43T, N88D | I13V, I15V, K20T, E35D, M36I, N37D, R41RK, R57K, I62V, L63P, K70KN, A71V, I85IV, L89LM, Q92QK, T96S |
| >1768-30522| codons 4-99 TLWQRPFVTVKVGGQLTEALLDTGADNTVFEDIDLPGKWTPKMIGGIGGFLKVKQYDQVP IEICGHNVIGTVLVGPTPCNIVGRDMMTKIGCSLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |