Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1575 | 1575-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73C | E35D, M36MI, K55R, I62V, L63P, I66V, I72IL | C95M |
| >1575-30417| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVRVRQYDQVP IEVCGHKALCTVLVGPTPVNVIGRNLMTQIGMTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74IV, Y115F, M184V, T215Y | K219Q | K101E, Y181C, G190A | A98G, V108I | T39TA, V106I, D123E, D177E, V179I, G196E, H208Y, R211K, D218E, H221Y, V245K |
| >1575-30417| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSITILDVGDAFFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIICQYVDDLYVASDLEIEQHRTKIEELRQYLLKWGFYTP EQKYQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |