Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1565 | 1565-30225 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, T215F | D67G, K219E | L100I, K103N | S68G, A98S, K102R, K122E, T200I, R211T, L228H, V245M |
| >1565-30225| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKGGTRWRKVVDFRELNKRTQDFWEVQLGIPHP SGIKRNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRIKIEELRQHLLTWGFFTP DEKHQKEPPFHWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, L76V, V82A, L90M | F53L | L10I, I15V, K20R, M36I, I62V, L63AP, A71V, I72V, I93L |
| >1565-30225| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEEINLPGRWKPKMIMGIGGLVKVRQYDQVP IEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |