Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1562 | 1562-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L10F, L24I, L33F, K43T | T12Q, I13V, L19I, M36MI, K55KR, I62V, L63P, C67E, L89M, T91V |
| >1562-30610| codons 4-99 TLWQRPFVQVKIGGQIKEALIDTGADDTVFEEINLPGRWTPKIIGGIGGFVRVRQYDQVP IEIEGHKAIGTVVVGPTPANIIGRNMLVQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, L210W | T215E, K219Q | K103KN, Y188L | K64H, T69N, K102MR, I135T, D177DG, V179VI, G196E, I202IV, R211RK, D218E, L228H |
| >1562-30610| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPGIIIYQYVDDLLVGSDLEIEQHRTKVEELRQHLWKWGFETP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |