Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1554 | 1554-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | L100I, K103N | K66KR, K122E, A158S, K166R, D177A, G196A, T200I, D218E, L228R |
| >1554-30625| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKRNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQSSMTRILEPFRKQNPAIVIYQYMDDLYVGSDLEIAQHRIKIEELRQHLLRWGFFTP EQKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54V, V82A, L90M | L33F, F53L, L89V | L10I, I13V, K20R, M36I, L63P, A71I |
| >1554-30625| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTIFEEINLPGRWKPKMIGGIGGLVKVRQYDQIP IEICGHKIIGTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |