Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1548 | 1548-30811 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V | L10I, I15V, E35D, M36I, N37Q, R41K, L63T, I93L |
| >1548-30811| codons 4-98 TLWQRPIVTIKVGGQLKEALLDTGADDTVLEDIQLPGKWKPKIIGGIGGFVKVRQYDQIT IEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M, M184MV | K219Q | K103N | K122P, I142V, S162A, I178L, T200A, E204K, Q207E, R211K, F214L |
| >1548-30811| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGVRYQYNVLPMGWKGSP AIFQASMTKILEPFRKQNPDLVIYQYVDDLYVGSDLEIGQHRAKIEKLREHLLKWGLTTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |