Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1550 | 1550-30811 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11VI, G73C | L10V, I13M, Q18R, K20I, E34EQ, E35D, M36I, N37D, K45R, I62V, L63P, C67F, H69Q, A71AV, I72V, T91S |
| >1550-30811| codons 4-99 TLWQRPVITMKIGGRLIEALLDTGADDTVLQDIDLPGRWKPRMIGGIGGFVKVRQYDQVP IEIFGQKVVCTVLVGPTPANIIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KNRS | K103N | V108VI | K43N, E44D, V118I, D121H, K122E, S162C, I178L, V179VI, R211K, K223T, V245T |
| >1550-30811| codons 38-247 CTELENDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDLIIYQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DSKHQTEPPFLWMGYELHPDKWTVQPITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |